Method for inhibiting apoptosis induced by photodynamic therapy using a cysteine or serine protease inhibitor
US6180402A · kind A · utility
16Cited by
5References
7Claims
0Family size
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Key dates
| Filing date | Nov 20, 1996 |
| Grant date | Jan 30, 2001 |
| Priority date | — |
| Expiry date | Nov 20, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/37
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition and method for inhibiting apoptosis, or decreasing the rate or extent of apoptosis, in target cells. The method comprises the step of the step of contacting the target cells with an apoptosis-regulating amount of at least one cysteine or serine protease inhibitor that: PA1 a. inhibits the conversion of the pro-enzyme form of CPP32 to its enzymatically-active form; PA1 b. blocks the proteolytic action of activated CPP32 against its cellular substrates; or PA1 c. both. The method is particularly applicable to ameliorating the side effects of, or enhancing the selectivity, of photodynamic therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.