Methods of modulating serine/threonine protein kinase function with 5-azaquinoxaline-based compounds

US6180631A · kind A · utility

Assignee

• Asta Medica Aktiengesellschaft · DE

Inventors

• Gerald McMahon · San Francisco, US
• Heinz Weinberger · Pocking, DE
• Bernhard Kutscher · Maintal, DE
• Harald App · Hillsborough, US

Key dates

• Filing date: Oct 5, 1998
• Grant date: Jan 30, 2001
• Expiry date: Oct 5, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed in part towards methods of modulating the function of serine/threonine protein kinases with 5-azaquinoxaline-based compounds. The methods incorporate cells that express a serine/threonine protein kinase, such as RAF. In addition, the invention describes methods of preventing and treating serine/threonine protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to 5-azaquinoxaline compounds and pharmaceutical compositions comprising these compounds.