Peptide nucleic acid conjugates
US6180767A · kind A · utility
22Cited by
5References
34Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 7, 1997 |
| Grant date | Jan 30, 2001 |
| Priority date | — |
| Expiry date | Jan 7, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/003
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Peptide nucleic acid (PNA) oligomers are conjugated to a ligand which is capable of binding to a cell surface receptor. The ligand facilitates cellular uptake of the PNA oligomer. Where the ligand is a peptide, the conjugate may be produced as a unitary molecule by first synthesizing the peptide ligand by solid phase or solution peptide synthesis, followed by synthesis of the PNA oligomer as an extension of the peptide ligand. The PNA oligomer base sequence is selected to hybridize to a target polynucleotide sequence by either triplex (dsDNA) or duplex (ssDNA; RNA) formation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.