Process for the catalytic enantioselective reduction of ketones

US6180837A · kind A · utility

Assignees

• Degussa-Huels AG · DE
• Forschungszentrum Jülich GmbH · DE

Inventors

• Guido Giffels · Bonn, DE
• Marcel Felder · Dottikon, CH
• Udo Kragl · Kritzmow, DE
• Christian Wandrey · Jülich, DE
• Andreas Bommarius · Frankfurt, DE
• Carsten Bolm · Aachen, DE
• Nadine Derrien · Cambridge, GB
• Karlheinz Drauz · Alzenau, DE

Key dates

• Filing date: Jul 13, 1999
• Grant date: Jan 30, 2001
• Expiry date: Jul 13, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention involves a procedure for the catalytic enantioselective reduction of ketones to chiral alcohols. Heretofore, this reaction was carried out batch-wise. Because, in this procedure, one utilizes a catalyst increased in size with polymer, it is possible to carry out the reaction in a quasi-continuous manner in a membrane reactor. In contrast to the state of the art, one thus dramatically increases the operative life of the catalyst.