Apparatus and method for selectively ranking sequences for antisense targeting
US6183966A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 22, 1999 |
| Grant date | Feb 6, 2001 |
| Priority date | — |
| Expiry date | Jan 22, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B20/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The invention provides methods of identifying a nucleic acid molecule having a sequence capable of targeting a gene of interest, and hence nucleic acid molecules useful in gene theraphy and disease treatment. A system and method for selecting antisense DNA oligonucleotide sequences that will form the most stable DNA:RNA hybrids within a given target mRNA sequence is provided. An apparatus capable of identifying a subject nucleic acid sequence capable of targeting a gene of interest is further provided. The apparatus includes the use of a software program and a computing unit. Methods for controlling gene expression are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.