Patent · US Expired

Method for the fermentative production of D-pantothenic acid using strains of the family enterobacteriaceae

US6184006A · kind A · utility

9Cited by

1References

5Claims

0Family size

Assignee

Degussa-Huels AG · DE

Inventors

Mechthild Rieping · Bielefeld, DE
Georg Thierbach · Bielefeld, DE
Walter Pfefferle · Bodenwerder, DE
Nicole Dusch · Bielefeld, DE
Jorn Kalinowski · Bielefeld, DE
Alfred Puhler · Bielefeld, DE

Key dates

Filing date	May 26, 1999
Grant date	Feb 6, 2001
Priority date	—
Expiry date	May 26, 2019

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P13/02
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A method for the production of D-pantothenic acid by the fermentation of microorganisms of the family Enterobacteriacae producing D-pantothenic acid which is characterized in that strains are used which PA1 a) Contain the plasmid pFV31 and/or pFV202 and that PA1 b) A panD gene and optionally other nucleotide sequences coding for aspartate-1-decarboxylase are enhanced, especially overexpressed in these microorganisms, PA1 c) The pantothenic acid is enriched in the medium or in the cells of the microorganisms and PA1 d) The pantothenic acid formed is isolated.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.