Dipeptide apoptosis inhibitors and the use thereof
US6184210A · kind A · utility
32Cited by
13References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 16, 1999 |
| Grant date | Feb 6, 2001 |
| Priority date | — |
| Expiry date | Mar 16, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/40
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to novel dipeptides thereof, represented by the general Formula I: ##STR1## where R.sub.1 -R.sub.3 and AA are defined herein. The present invention relates to the discovery that compounds having Formula I are potent inhibitors of apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.