Inhibition of DNA methyltransferase
US6184211A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 30, 1996 |
| Grant date | Feb 6, 2001 |
| Priority date | — |
| Expiry date | May 30, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/111
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the interplay between the level of DNA methyltransferase and demethylase activities, to the role of the interplay between these levels on the proliferative, differentiated, tumorigenic and homeostatic state of the cell, and to the DNA methyltransferase and demethylase as therapeutic targets. The invention further relates to a reduction of the level of DNA methylation through inhibitors and antagonist in order to inhibit the excessive activity or hypermethylation of DNA MeTase in cancer cells to induce the original cellular tumor suppressing program, to turn on alternative gene expression programs, to provide therapeutics directed at a nodal point of regulation of genetic information, and to modulate the general level of methylase and demethylase enzymatic activity of a cell to permit specific changes in the methylation pattern of a cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.