Quinazoline derivatives as VEGF inhibitors
US6184225A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 13, 1998 |
| Grant date | Feb 6, 2001 |
| Priority date | — |
| Expiry date | Aug 13, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/94
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to quinazoline derivatives of formula (I) ##STR1## wherein: Z represents --O--, --NH-- or --S--; m is an integer from 1 to 5; R.sup.1 represents hydrogen, hydroxy, halogeno, nitro, trifluorometlyl, cyano, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkylthio or NR.sup.5 R.sup.6 (wherein R.sup.5 and R.sup.6, which may be the same or different, each represents hydrogen or C.sub.1-3 alkyl); R.sup.2 represents hydrogen, hydroxy, halogeno, methoxy, amino, or nitro; R.sup.3 represents hydroxy, halogeno, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkanoyloxy, trifluoromethyl, cyano, amino or nitro; X.sup.1 represents --O--, --CH.sub.2 --, --S--, --SO--, SO.sub.2 --, --NR.sup.6 --, NR.sup.8 CO--, --CONR.sup.9 --SO.sub.2 NR.sup.10 -- or --NR.sup.11 SO.sub.2 --, (wherein R.sup.7, R.sup.8, R.sup.9, R.sup.10 and R.sup.11 each represents C.sub.1-3 alkyl, C.sub.1-3 alkoxyC.sub.2-3 alkyl); R.sup.4 represents a group which is alkenyl, alkynyl or optionally substituted alkyl, which alkyl group may contain a heteroatom linking group, which alkenyl, alkynyl or alkyl group may carry a terminal optionally substituted 5 or 6 membered saturated carbocylic or heterocyclic group; a…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.