Rhodamine derivatives and the use thereof

US6184379A · kind A · utility

Assignee

• Roche Diagnostics GMBH · DE

Inventors

• Hans-Peter Josel · Weilheim, DE
• Rupert Herrmann · Weilheim, DE
• Dieter Heindl · Munich, DE
• Klaus Muhlegger · Polling, DE
• Gregor Sagner · Penzberg, DE
• Karl-Heinz Drexhage · Rochester, US
• Jörg Frantzeskos · Wenden, DE
• Jutta Arden-Jacob · Zirndorf, DE

Key dates

• Filing date: Jun 2, 1999
• Grant date: Feb 6, 2001
• Expiry date: Jun 2, 2019

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S436/80
• WIPO field: Basic materials chemistry
• WIPO sector: Chemistry

Abstract

The invention concerns rhodamine derivatives of the general formulae ##STR1## in which Ca-Cd each denote a C atom, and Ca and Cb as well as Cc and Cd are either linked together by a single bond or by a double bond; X1 to X16 denote independently of one another halogen, sulfonic acid, hydrogen or an alkyl residue with 1-20 C atoms in which the alkyl residue can be substituted with one or several halogen or sulfonic acid residues; R1 and R2 are either identical or different and denote either hydrogen, alkyl with 1-20 C atoms, polyoxyhydrocarbyl units, phenyl or phenylalkyl with 1-3 carbon atoms in the alkyl chain in which the alkyl and/or phenyl residues can be substituted by one or several hydroxy, halogen, sulfonic acid, amino, carboxy or alkoxycarbonyl groups where alkoxy can have 1-4 carbon atoms, R1 contains at least one activatable group, R2 and X4 can be optionally linked together via a bridge composed of 0-2 C atoms. In contrast to the prior art, these compounds are characterized in that A1, A2 and A3 can independently of one another denote hydrogen, cyano, halogen and sulfonic acid; B1 denotes either halogen, cyano or hydrogen; B2 denotes hydrogen, amide, halogen and an alky…