Patent · US Expired

Method for preparing acetophenones with a fluoralkyl-substituted aromatic nucleus

US6184417A · kind A · utility

1Cited by

1References

9Claims

0Family size

Assignee

BAYER HEALTHCARE LLC · DE

Inventors

Wulf Kuhnle · Neunburg vorm Wald, DE
Albrecht Marhold · Leverkusen, DE
Guido Steffan · Odenthal, DE

Key dates

Filing date	Nov 1, 1999
Grant date	Feb 6, 2001
Priority date	—
Expiry date	Nov 1, 2019

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C45/00
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Acetophenones which are substituted on the aromatic ring by fluoroalkyl are prepared in a particularly advantageous, environmentally friendly and effective manner from fluoroalkylanilines and acetaldoxime by preparing from a fluoroalkylaniline a corresponding diazonium salt solution, and reacting this with acetaldoxime in the presence of at least one copper compound, without adding any buffer salts or reducing agents, carrying out the reaction at from 20 to 50.degree. C. and in the presence of halide ions and subsequently heating to a temperature in the range from 70 to 110.degree. C.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.