Patent · US Expired

Assymetrically substituted xanthine derivatives having adenosine A1 antagonistic activity

US6187780A · kind A · utility

11Cited by

0References

9Claims

0Family size

Assignee

BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

Stefan Blech · Warthausen, DE
Adrian Carter · Bingen, DE
Wolfram Gaida · Ingelheim am Rhein, DE
Ursula Gath · Bad Iburg, DE
Matthias Hoffmann · Mittelbiberach, DE
Ulrike Kuefner-Muehl · Ingelheim am Rhein, DE
Erich Lehr · Waldalgesheim, DE
Joachim Mierau · Mainz, DE
Gerald Pohl · Gau-Algesheim, DE
Thomas Weiser · Nieder-Olm, DE

Key dates

Filing date	Apr 7, 1999
Grant date	Feb 13, 2001
Priority date	—
Expiry date	Apr 7, 2019

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D473/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Asymmetrically substituted xanthine derivatives having adenosine A.sub.1 antagonistic activity. These are useful as pharmaceuticals. Exemplary are: PA1 (a) 3-(2-(2-acetyloxyethyl)sulphonylethyl)-8-(1-noradamantyl)-1-n-propyl-xanth ine; PA1 (b) 3-(2-(hydroxyethyl)sulphonylethyl)-8-(1-noradamantyl)-1-n-propyl-xanthine; and, PA1 (c) 3-(2-(carbamoylethyl)-8-(1-noradanantyl)-1-n-propyl-xanthine.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.