Patent · US Expired

Substituted isoquinolines as ultra short acting neuromuscular blockers

US6187789A · kind A · utility

9Cited by

2References

7Claims

0Family size

Assignees

Glaxo Wellcome Inc. · US
Cornell Research Foundation, Inc. · US

Inventors

Eric C. Bigham · Chapel Hill, US
Grady Evan Boswell · Cary, US
John J. Savarese · Boxford, US
Roy A. Swaringen, Jr. · Durham, US
Sanjay Shashikant Patel · Cary, US
Eric Eugene Boros · Durham, US
Robert Mook · Chapel Hill, US
Vincente Samano · Chapel Hill, US

Key dates

Filing date	Jan 19, 2000
Grant date	Feb 13, 2001
Priority date	—
Expiry date	Jan 19, 2020

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D217/20
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Ultrashort acting neuromuscular blocking agents of Formula (I) which are useful as skeletal muscle relaxants during emergency intubation procedures, routine surgery and post-operative settings are disclosed, wherein: X is a halogen; h is from 1 to 2; Y is hydrogen or methoxy; Z.sup.1 and Z.sup.2 are methyl; W.sup.1 and W.sup.2 are carbon; and A is a pharmaceutically acceptable anion.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.