Inhibition of raf kinase activity using aryl ureas

US6187799A · kind A · utility

Assignees

• Onyx Pharmaceuticals, Inc. · US
• BAYER HEALTHCARE LLC · DE

Inventors

• Jill Wood · Hampton, US
• Hanno Wild · Wuppertal, DE
• Daniel Rogers · San Diego, US
• John Francis Lyons · London, GB
• Michael Katz · Wallingford, US
• Yolanda Caringal · Lawrenceville, US
• Robert Dally · Indianapolis, US
• Wendy Lee · Hamden, US
• Roger Smith · Madison, US
• Cheri Blum · Alameda, US

Key dates

• Filing date: May 22, 1998
• Grant date: Feb 13, 2001
• Expiry date: May 22, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.