Two-step production of 3-chloro-4-fluoro-benzoyl chloride by chlorination

US6187952A · kind A · utility

Assignee

• Clariant Corporation · DE

Inventors

• Ralf Pfirmann · Griesheim, DE
• Thomas Wessel · Frankfurt, DE

Key dates

• Filing date: Dec 10, 1998
• Grant date: Feb 13, 2001
• Expiry date: Dec 10, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C51/62
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the preparation of 3-chloro-4-fluorobenzoyl chloride which comprises reacting 4-fluorobenzaldehyde with a chlorinating agent in the presence of a free-radical initiator in the presence or absence of a solvent at from -20 to 200.degree. C. to give 4-fluorobenzoyl chloride, and reacting the 4-fluorobenzoyl chloride with a chlorinating agent in the presence of a chlorination catalyst in the presence or absence of a solvent at from -20 to 200.degree. C. to give 3-chloro-4-fluorobenzoyl chloride.