Bacterial plasmin binding protein and methods of use thereof
US6190659A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 17, 1996 |
| Grant date | Feb 20, 2001 |
| Priority date | — |
| Expiry date | Sep 17, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/825
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention describes a novel polypeptide, and methods of its use in effective thrombolytic therapy in the treatment of coronary and pulmonary thrombosis. Its use is also disclosed in vaccines to abrogate a streptococcal infection. Pharmaceutical compositions containing the novel polypeptide are included. One particular form of the novel polypeptide is streptococcal surface enolase (SEN), a specific binding protein for human plasmin and/or human plasminogen on group A streptococci that displays classical .alpha.-enolase activity, i.e., it can catalyze the dehydration of D-glycerate-2-phosphate to phosphoenolpyruvate. In addition, SEN impedes the inhibition of the fibrinolytic activity of plasmin by .alpha..sub.2 -antiplasmin and can bind plasminogen without preventing streptokinase from cleaving this plasmin precursor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.