Methods for modulating metabolic pathways of micro-organisms and micro-organisms obtainable by said methods
US6190914A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 14, 1999 |
| Grant date | Feb 20, 2001 |
| Priority date | — |
| Expiry date | Jun 14, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02E50/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides methods for changing the metabolic pathways of micro-organisms in the presence of a certain carbon source and uses of such changes, as well as micro-organisms and uses of such changes, as well as micro-organisms produced by these methods. In a preferred embodiment the invention provides new yeast strains with improved biomass yields, a process to obtain these yeasts and the potential application of these yeasts are provided. The biomass yield is improved by the introduction into a yeast of a DNA construct conferring altered expression of a gene encoding a protein controlling transcription of a number of glucose-repressed genes. The yeasts are less sensitive to glucose repression, resulting in an increase in respiratory capacity, reduction of ethanol production and increased conversion of sugar into biomass.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.