Cyclohexane derivatives difunctionalised in 1,4 as ligands of 5T H1A receptors
US6191130A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 14, 2000 |
| Grant date | Feb 20, 2001 |
| Priority date | — |
| Expiry date | Apr 14, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
##STR1## The invention concerns novel cyclohexane derivatives difunctionalised in 1.4 of general formula (1) in which A represents a group such as (IIa) in which Ar itself represents an aromatic structure such as phenyl or pyrimidinyl optionally substituted by one or several groups such as C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, trifluoromethyl or halogen (IIb); B represents a heterocyclic group such as: 3,5-dioxo-(2H,4H)-1,2,4 triazine substituted in position 2 (IIIa); 3-oxo-(2H)-1,2,4 triazine substituted in position 5 (IIIb); 3,5-dioxo-6-amino-(2H,4H)-1,2,4-triazine (IIIc) in which R represents a C.sub.1 -C.sub.3 alkyl group. The invention also concerns the salts of compounds of general formula I with pharmaceutically acceptable acids. It also concerns the various "cis" and "trans" isomers and the various enantiomers with asymmetric carbons.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.