Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them

US6191164A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Hans-Jochen Lang · Hofheim, DE
• Uwe Gerlach · Hattersheim, DE
• Joachim Brendel · Bad Vilbel, DE
• Henrich Christian Englert · Hofheim, DE
• Heinz Gogelein · Frankfurt am Main, DE
• Max Hropot · Flörsheim, DE
• Helmut Bohn · Schöneck, DE
• Andreas Herling · Bad Camberg, DE
• Andreas Busch · Kelkheim, DE
• Rainer Greger · Heitersheim, DE

Key dates

• Filing date: Feb 26, 1999
• Grant date: Feb 20, 2001
• Expiry date: Feb 26, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/353
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or a diagnostic, and medicament comprising them Chromans of the formula I ##STR1## and of the formula 1a ##STR2## having the meanings R(A), R(B), R(C) and R(1) to R(8) indicated in the claims are outstandingly suitable for preparing a medicament for blocking the K.sup.+ channel which is opened by cyclic adenosine monophosphate (cAMP); and further for preparing a medicament for inhibiting gastric acid secretion; for the treatment of ulcers of the stomach and of the intestinal region, in particular of the duodenum, for the treatment of reflux esophagitis, for the treatment of diarrheal illnesses, for the treatment and prevention of all types of arrhythmias including ventricular and supraventricular arrhythmias, and for the control of reentry arrhythmias and for the prevention of sudden heart death as a result of ventricular fibrillation.