Antimicrobial cationic peptides

US6191254A · kind A · utility

Assignee

• University of British Columbia · CA

Inventors

• Timothy J. Falla · Woodinville, US
• Robert E. W. Hancock · Vancouver, CA
• Monisha Gough · Vancouver, CA

Key dates

• Filing date: Aug 23, 1996
• Grant date: Feb 20, 2001
• Expiry date: Aug 23, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A novel class of cationic peptides having antimicrobial activity is disclosed. These peptides can be encompassed by the formulas: X.sub.1 X.sub.1 PX.sub.2 X.sub.3 X.sub.2 P(X.sub.2 X.sub.2 P).sub.n X.sub.2 X.sub.3 (X.sub.5).sub.o ; (SEQ ID NO: 23) X.sub.1 X.sub.1 PX.sub.2 X.sub.3 X.sub.4 (X.sub.5).sub.r PX.sub.2 X.sub.3 X.sub.3 ; (SEQ ID NO: 24) X.sub.1 X.sub.1 X.sub.3 (PW).sub.u X.sub.3 X.sub.2 X.sub.5 X.sub.2 X.sub.2 X.sub.5 X.sub.2 (X.sub.5).sub.o ; and (SEQ ID NO: 25) X.sub.1 X.sub.1 X.sub.3 X.sub.3 X.sub.2 P(X.sub.2 X.sub.2 P).sub.n X.sub.2 (X.sub.5).sub.m ; (SEQ ID NO: 26) wherein: PA1 m is 1 to 5; PA1 n is 1 or 2; PA1 o is 2 to 5; PA1 r is 0 to 8; PA1 u is 0 or 1; PA1 X.sub.1 is Isoleucine, Leucine, Valine, Phenylalanine, Tyrosine, Tryptophan or Methionine; PA1 X.sub.2 represents Tryptophan or Phenylalanine PA1 X.sub.3 represents Arginine or Lysine; PA1 X.sub.4 represents Tryptophan or Lysine; and PA1 X.sub.5 represents Phenylalanine, Tryptophan, Arginine, Lysine, or Proline. The invention also provides a method of producing a cationic peptide variant having antimicrobial activity.