Substituted 5-membered ring heterocycles comprising a bicyclic or tricyclic group their preparation and their use

US6191282A · kind A · utility

Assignee

• Hoechst Marion Roussel · FR

Inventors

• Gerhard Zoller · Blankenloch, DE
• Otmar Klingler · Rodgau, DE
• Bernd Jablonka · Bad Soden, DE
• Melitta Just · Langen, DE
• Gerhard Breipohl · Scheinfeld, DE
• Jochen Knolle · Kriftel, DE
• Wolfgang Konig · Hofheim, DE
• Hans Ulrich Stilz · Frankfurt am Main, DE

Key dates

• Filing date: Jul 28, 1999
• Grant date: Feb 20, 2001
• Expiry date: Jul 28, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

5-Membered ring heterocycle of the formula I, ##STR1## in which D includes a COOR.sup.15, CON(CH.sub.3)R.sup.15 or CONHR.sup.15 radical and R.sup.15 includes a 6-24 member bicyclic or tricyclic radical, compositions, preparation and use as inhibitors of thrombocyte aggregation, metastasization of carcinoma cells, binding of osteoclasts to bone surfaces and for the treatment of tromboses.