Method for preparing a pharmaceutical composition with modified release of the active principle, comprising a matrix
US6194005A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 23, 1999 |
| Grant date | Feb 27, 2001 |
| Priority date | — |
| Expiry date | Mar 23, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2077
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns a method for preparing a modified release of active principle. The method comprises the steps of mixing a powder composed of active principle, adjuvant or combinations thereof while heating and fluidizing in order to obtain individual grains, liquefying a lipid matrix agent composed of partial esters of alcohol with at least one fatty acid, coating the powder by spraying from 1 to 15% by weight of the final composition liquid lipid matrix agent over the individual grains, the spraying air pressure, and optionally the spraying rate varying throughout the coating operation and lowering the temperature of the combined product to allow the lipid matrix agent to solidify around the grains.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.