DNA encoding a hybrid heterodimeric protein
US6194177A · kind A · utility
11Cited by
6References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 14, 1997 |
| Grant date | Feb 27, 2001 |
| Priority date | — |
| Expiry date | Aug 14, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-.beta.and TPO, linked to a subunit of a heterodimeric proteinaceous hormone, such as hCG. Each coexpressed sequence contains a corresponding hormone subunit so as to form a heterodimer upon expression. Corresponding DNA molecules, expression vectors and host cells are also disclosed as are pharmaceutical compositions and a method of producing such proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.