Fermentative preparation process for and crystal forms of cytostatics

US6194181A · kind A · utility

Assignee

• Novartis AG · CH

Inventors

• Hans Hofmann · Odenthal, DE
• Marion Mahnke · Steinen, DE
• Klaus Memmert · Lörrach, DE
• Frank Petersen · Weil am Rhein, DE
• Thomas Schupp · Möhlin, CH
• Ernst Kusters · Sankt Goarshausen, DE
• Michael Mutz · Glückstadt, DE

Key dates

• Filing date: Feb 12, 1999
• Grant date: Feb 27, 2001
• Expiry date: Feb 12, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/01
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.