Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof

US6194383A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Peter Hammann · Kelkheim, DE
• Johannes Meiwes · Idstein, DE
• Gerhard Seibert · Darmstadt, DE
• Laszlo Vertesy · Eppstein, DE
• Joachim Wink · Rödermark, DE
• Astrid Markus · Liederbach, DE

Key dates

• Filing date: Mar 5, 1997
• Grant date: Feb 27, 2001
• Expiry date: Mar 5, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/827
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to lipopeptides with very homologous amino-acid sequences but different fatty acid residues (lipid portion) which are synthesized by Actinoplanes sp. during fermentation and are released into the culture medium, to a process for isolating the lipopeptides from the culture medium and purifying them, to the use of the lipopeptides as pharmacologically active substances, in particular against Gram-positive bacteria, and to Actinoplanes sp. DSM 7358 for producing the abovementioned lipopeptides.