3(2H)-pyridazinone derivatives and pharmaceutical compositions containing these compounds
US6194411A · kind A · utility
Assignee
Inventors
- Peter Matyus
- Laszlo Harsing
- Mariann nee Tapfer Karim
- Judit Kosary
- Agnes nee Behr Papp
- Antal Simay
- Yemane Tilahun
- Eva nee Joszt Tomori
- Edit Horvath
- Katalin Horvath
- Ildiko Varga
- Erzsebet nee Kaczian Zara
- Margit nee Igloy Bidlo
- Alice Druga
- Gyorgy Rabloczky
- Marta Varga
- Egon Karpati
- Endre Kasztreiner
- Istvan Kiraly
- Ildiko nee Gyory Mathe
- Gyorgy Mathe
- Laszlo Sebestyen
- Nandor Makk
Key dates
| Filing date | Jul 20, 1998 |
| Grant date | Feb 27, 2001 |
| Priority date | — |
| Expiry date | Jul 20, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D319/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to R-2-[3-([1,4]benzodioxan-2-ylmethylamino)-1-propyl]-3(2H)-pyridazionone of formula (1) ##STR1## and to S-2-[3-([1,4]benzodioxan-2-ylmethylamino)-1-propyl]-3(2H)-pyridazionone of formula (2) ##STR2## and to acid-addition salts thereof as well as pharmaceutical compositions containing these compounds. Furthermore, the invention relates to a process for the preparation of the above compounds. The new starting compounds of formula (4) and (5) are also involved in the scope of the invention. The compounds according to the invention possess .alpha..sub.1 - and .alpha..sub.2 -adrenoceptor antagonistic effects and urogenital selectivity. Thus, they are useful for the treatment of the benign prostate hyperplasia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.