Matrix metalloproteinase inhibitors

US6194451A · kind A · utility

Assignee

• Pharmacia & Upjohn S.p.A. · IT

Inventors

• Marco Alpegiani · Milano, IT
• Massimiliano Palladino · Legnano, IT
• Riccardo Corigli · Milano, IT
• Daniela Jabes · Milano, IT
• Ettore Perrone · Milano, IT
• Maria Francesca Abrate · Milano, IT
• Pierluigi Bissolino · Pavia, IT
• Marina Lombroso · Milano, IT

Key dates

• Filing date: Jul 30, 1999
• Grant date: Feb 27, 2001
• Expiry date: Jul 30, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

##STR1## A compound of formula (I), wherein W is --NHOH or --OH, R.sub.1 is either free or protected hydroxymethyl or mercaptomethyl or derivatives thereof, R.sub.2 is free or protected hydroxy, R.sub.3 and R.sub.4 is an organic group, R.sub.5 is hydrogen or methyl, or R.sub.4 and R.sub.5, together with the nitrogen atom to which they are attached, constitute an azaheterocyclyl group, and the solvates, hydrates and pharmaceutically acceptable salts thereof, can inhibit matrix metalloproteinases and the release of tumour necrosis factor (TNF). Processes for producing the compound, intermediates involved in the processes, and pharmaceutical compositions containing the compound are also described.