Dendritic polypeptides

US6194543A · kind A · utility

Assignee

• The school of Pharmacy University · GB

Inventors

• Alexander T Florence · London, GB
• Thiagarajan Sakthivel · London, GB
• Andrew F Wilderspin · London, GB
• Istvan Toth · Brisbane, AU

Key dates

• Filing date: Jun 11, 1998
• Grant date: Feb 27, 2001
• Expiry date: Jun 11, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A dendritic compound comprises two dendrons, each comprising dendritically linked amino acid units, preferably lysine units, joined to a focal group. One of the dendrons includes terminal branches including anchor groups constituted by hydrophobic units and the second dendron has terminal branches which are linked or may be linked to active ligands or sugar moieties. Methods for synthesising the dendritic compounds using solid phase peptide synthetic techniques including lipidic amino acid reagents is described. The compounds serve as a basis for multiple antigenic peptides or drug delivery systems.