Process for synthesizing carbapenem intermediates
US6194568A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 4, 1999 |
| Grant date | Feb 27, 2001 |
| Priority date | — |
| Expiry date | Jun 4, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention describes an improved process for synthesizing 1-.beta.-methyl-2-hydroxymethyl substituted carbapenems as key intermediates for the synthesis of anti-MRSA carbapenem antibiotics. The synthesis eliminates the use of BU.sub.3 SnCH.sub.2 OH and HMPA, which are toxic substances and not amenable to industrial scale production. The novel intermediates are also within the scope of this invention. The invention relates to the synthesis of a compound of formula 3: ##STR1## wherein R.sup.1 represents H or a suitable protecting group for an alcohol; R.sup.2 represents H or methyl; and R.sup.5 represents a carboxy protecting group as well as the compounds made therein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.