Method of stimulating T cells
US6197302A · kind A · utility
46Cited by
6References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 19, 1997 |
| Grant date | Mar 6, 2001 |
| Priority date | — |
| Expiry date | Aug 19, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/807
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention describes a soluble fusion protein composed of a plurality of major histocompatibility complex (MHC) molecules linked together by a stabilizing structure herein referred to as the "linker," the MHC molecules being loaded with a specific peptide or peptides. Such fusion proteins can be used as a method for stimulating or inhibiting specific T cell clones expressing T cell receptors (TCR) restricted to the specific MHC-peptide combination. Such fusion proteins can thus be used as delivery systems to stimulate T cell immunity and as a treatment for diseases such as transplant rejection or autoimmunity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.