Bioadhesive microspheres and their use as drug delivery and imaging systems
US6197346A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 24, 1992 |
| Grant date | Mar 6, 2001 |
| Priority date | — |
| Expiry date | Apr 24, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/929
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, diagnostic, or diagnostic purposes in diseases of the gastrointestinal tract, are described. The polymeric microspheres all have a bioadhesive force of at least 11 mN/cm.sup.2 (110 N/CM.sup.2). Techniques for the fabrication of bioadhesive microspheres, as well as a method for measuring bioadhesive forces between microspheres and selected segments of the gastrointestinal tract in vitro are also described. This quantitative method provides a means to establish a correlation between the chemical nature, the surface morphology and the dimensions of drug-loaded microspheres on one hand and bioadhesive forces on the other, allowing the screening of the most promising materials from a relatively large group of natural and synthetic polymers which, from theoretical consideration, should be used for making bioadhesive microspheres.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.