Arrangement of nucleic acid sequences for comparative genomic hybridization

US6197501A · kind A · utility

Assignee

• Deutsches Krebsforschungszentrum · DE

Inventors

• Thomas Cremer · Heidelberg, DE
• Thomas Ried · Bethesda, US
• Michael Speicher · Ottobrunn, DE
• Anna Jauch · Heddesheim, DE
• Peter Lichter · Heidelberg, DE

Key dates

• Filing date: Jun 24, 1996
• Grant date: Mar 6, 2001
• Expiry date: Jun 24, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/6841
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A method of determining the relative number of nucleic acid sequences in test cells which provides for a high resolution during comparative genomic hybridization by keeping all components separate from each other and selecting target nucleic acids which have a high resolution capability for determining genomic imbalances in the test cells and which facilitate a screening of the test cells for over- or under-expression of individual genes.