Patent · US Expired

Methods for assessing cardiovascular status and compositions for use thereof

US6197505A · kind A · utility

11Cited by

4References

40Claims

0Family size

Assignee

Pyrosequencing AB · SE

Inventors

Leif Torbjorn Norberg · Uppsala, SE
Maria Andersson · Uppsala, SE
Per Harry Rutger Lindstrom · Uppsala, SE

Key dates

Filing date	Mar 27, 1998
Grant date	Mar 6, 2001
Priority date	—
Expiry date	Mar 27, 2018

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/156
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides methods for assessing cardiovascular status in an individual, which comprise determining the sequence at one or more polymorphic positions within the human genes encoding angiotensin converting enzyme (ACE), angiotensinogen (AGT), and/or type 1 angiotensin II receptor (AT1). The invention also provides isolated nucleic acids encoding ACE, AGT, and AT1 polymorphisms, nucleic acid probes that hybridize to polymorphic positions, kits for the prediction of cardiovascular status, and nucleic acid and peptide targets for use in identifying candidate cardiovascular drugs.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.