Suppression of tumor growth by a mini-E1A gene
US6197754A · kind A · utility
12Cited by
16References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 20, 1997 |
| Grant date | Mar 6, 2001 |
| Priority date | — |
| Expiry date | Oct 20, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/10343
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods and compositions for the suppression of oncogenic transformation, tumorigenesis and metastasis. The present invention discloses functional domains of E1A responsible for the suppression of transformation, and provides mini-E1A constructs that can be used for tumor suppression. The invention also discloses methods for the novel use of mini-E1A in combination with chemotherapeutic drugs and/or tyrosine kinase inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.