Amino-benzocycloalkane derivatives

US6197798A · kind A · utility

Assignee

• Novartis AG · CH

Inventors

• Cynthia Fink · Lebanon, US
• Gary Michael Ksander · Carmel, US
• Paivi Jaana Kukkola · Whitehouse Station, US
• Eli M. Wallace · Richardson, US
• Mahavir Prashad · East Hanover, US

Key dates

• Filing date: Jul 20, 1999
• Grant date: Mar 6, 2001
• Expiry date: Jul 20, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I ##STR1## wherein PA1 R.sub.2 --C, R.sub.3 --C, R.sub.4 --C or R.sub.5 --C may be replaced by N; PA1 and wherein n is 1, 2 or 3; PA1 R.sub.1 is aryl, cycloalkyl or heterocyclyl; PA1 R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently hydrogen, optionally substituted alkyl, halo, amino, substituted amino, trifluoromethyl, cyano, carboxyl, alkoxycarbonyl, aralkoxycarbonyl, (alkyl, aryl or aralkyl)-thio, (alkyl, aryl or aralkyl)-oxy, acyloxy, (alkyl, aryl or aralkyl)-aminocarbonyloxy; or any two of R.sub.2, R.sub.3, R.sub.4 and R.sub.5 at adjacent positions are alkylenedioxy; PA1 R.sub.6 is hydrogen, optionally substituted alkyl, amino, substituted amino, acylamino, ##STR2## wherein PA1 R.sub.a is hydrogen or optionally substituted alkyl, PA1 R.sub.b and R.sub.c are independently hydrogen, optionally substituted alkyl, cycloalkyl, aryl or heterocyclyl; or R.sub.b and R.sub.c together represent lower alkylene or lower alkylene interrupted by O, S, or N--(H, alkyl or aralkyl); PA1 R.sub.d is optionally substituted alkyl, cycloalkyl, aryl or heterocyclyl; and PA1 R.sub.e is optionally substituted alkyl, aryl, heterocyclyl, cycloalkyl, amino or substituted am…