DNA molecules stabilized by modifications of the 3'-terminal phosphodiester linkage
US6197944A · kind A · utility
37Cited by
14References
36Claims
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Key dates
| Filing date | Jun 29, 1994 |
| Grant date | Mar 6, 2001 |
| Priority date | — |
| Expiry date | Jun 29, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.