Non-peptide peptidomimetics

US6197963A · kind A · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Ralph F. Hirschmann · La Cañada Flintridge, US
• John Hynes · Washington Crossing, US
• Maria Cichy-Knight · Collegeville, US
• Rachel Deborah van Rijn · Philadelphia, US
• Paul A. Sprengeler · San Diego, US
• P. Grant Spoors · Exton, US
• William C. Shakespeare · Framingham, US
• Sherrie Lynn Pietranico-Cole · Nutley, US
• Amos B. Smith, III · Yeadon, US

Key dates

• Filing date: Aug 13, 1998
• Grant date: Mar 6, 2001
• Expiry date: Aug 13, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H3/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds are provided which are crossreactive with peptides such as those which bind G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: ##STR1## PA1 wherein at least one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, or R.sub.5 comprises a functional group which is chemically similar to that found in the peptide of interest.