Process for producing N-glycyltyrosine and its crystal structure
US6197998A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 12, 1999 |
| Grant date | Mar 6, 2001 |
| Priority date | — |
| Expiry date | Apr 12, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C233/47
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided is a process for efficiently producing N-glycyltyrosine of high purity represented by the following formula: ##STR1## a salt thereof, or a solvate thereof, which comprises adding dropwise to an aqueous suspension of tyrosine or a salt thereof 2 equivalents or more of a haloacetyl halide and an aqueous solution of an inorganic base simultaneously in the presence or absence of an organic solvent, and subjecting the resulting N-haloacetyltyrosine to a reaction with an ammonium ion. Also provided are N-glycyl-L-tyrosine dehydrate having the crystal structures showing specific diffraction patterns in X-ray powder diffraction and processes for producing the same which are characterized by comprising crystallizing the dihydrate from an ethanol-water mixed solvent or water.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.