Method and apparatus for combining injury-mediated therapy and drug delivery

US6199554A · kind A · utility

Assignee

• The Brigham and Women's Hospital, Inc. · US

Inventors

• Michael J. Mann · San Francisco, US
• Umer Sayeed-Shah · Wappingers Falls, US
• Victor J. Dzau · Newton, US
• Lawrence H. Cohn · Sharon, US

Key dates

• Filing date: Mar 27, 1998
• Grant date: Mar 13, 2001
• Expiry date: Mar 27, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B2018/00392
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of enhancing injury-induced revascularization of a tissue as treatment of a disease, such as coronary artery disease, is described. The method involves (i) creating injury in a tissue (e.g., muscle, such as cardiac muscle) by, for example, use of a laser, an ultrasonic device, or a Thermal probe, and (ii) injecting into the tissue a revascularization-promoting molecule or a nucleic acid molecule encoding a revascularization-promoting molecules Also described is an apparatus that can be used to practice this method.