Adeno-associated virus vectors for expression of factor VIII by target cells
US6200560A · kind A · utility
105Cited by
0References
25Claims
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Assignee
Inventors
Key dates
| Filing date | Dec 22, 1999 |
| Grant date | Mar 13, 2001 |
| Priority date | — |
| Expiry date | Dec 22, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/85
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides improved viral vectors useful for the expression of genes at high levels in human cells. In particular, the present invention provides recombinant adeno-associated vectors (AAV) suitable for gene therapy. These vectors are capable of delivering nucleic acid containing constructs which result in the production of full-length therapeutic levels of biologically active Factor VIII in the recipient individual in vivo. The present invention also provides pharmaceutical compositions comprising such AAV vectors, as well as methods for making and using these constructs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.