Composition for enhanced uptake of polar drugs from the colon
US6200602A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 30, 1998 |
| Grant date | Mar 13, 2001 |
| Priority date | — |
| Expiry date | Mar 30, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a drug delivery composition for colonic delivery comprising a polar drug, an absorption promoter which (a) comprises a mixture of a fatty acid having 6 to 16 carbon atoms or a salt thereof and a dispersing agent, or (b) comprises a mixture of mono/diglycerides of medium chain fatty acids and a dispersing agent, and means adapted to release the polar drug and absorption promoter in the colon following oral administration. A preferred fatty acid is capric acid or a salt thereof. Colon specific delivery can be achieved by providing the composition in a capsule, tablet or pellet which is coated with a material which dissolves in the small intestine or is degraded by the conditions in the colon.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.