L-lysine-producing corynebacteria and process for the preparation of l-lysine

US6200785A · kind A · utility

Assignee

• Degussa-Huels AG · DE

Inventors

• Caroline Kreutzer · Melle, DE
• Stephan Hans · Osnabrück, DE
• Mechthild Rieping · Bielefeld, DE
• Bettina Mockel · Bielefeld, DE
• Walter Pfeffere · Halle, BE
• Lothar Eggeling · Jülich, DE
• Hermann Sahm · Jülich, DE
• Miroslav Patek · Praha, CZ

Key dates

• Filing date: Jul 14, 1999
• Grant date: Mar 13, 2001
• Expiry date: Jul 14, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P13/08
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to L-lysine-producing strains of corynebacteria with amplified lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dihydrodipicolinate reductase gene) and the pyc gene, but especially the dapA gene and the lysC gene (aspartate kinase gene), are amplified and, in particular, overexpressed, and to a process for the preparation of L-lysine.