Arylthiazolidinedione derivitives

US6200998A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Soumya P. Sahoo · Old Bridge, US
• Wei Han · Beaverton, US
• Richard L. Tolman · Hackettstown, US
• Jeffrey P. Bergman · Tenafly, US
• Conrad Santini · Hackettstown, US
• Ranjit C. Desai · Colonie, US
• Victoria K. Lombardo · Montgomery, US
• Julia Boueres · Willingboro, US
• Dominick F. Gratale · Edison, US

Key dates

• Filing date: Nov 23, 1999
• Grant date: Mar 13, 2001
• Expiry date: Nov 23, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted 5-aryl-2,4-thiazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other P.alpha., .delta. and/or .gamma. mediated diseases, disorders and conditions.