Z-styryl sulfone anticancer agents
US6201154A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 31, 1999 |
| Grant date | Mar 13, 2001 |
| Priority date | — |
| Expiry date | Mar 31, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C323/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
(Z)-styryl benzylsulfones of formula I are useful as anticancer agents: ##STR1## wherein PA1 R.sub.1 is selected from the group consisting of hydrogen, chloro and nitro; PA1 R.sub.2 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, chloro, bromo, and fluoro; and PA1 R.sub.3 and R.sub.4 are independently selected from the group consisting of hydrogen, lower alkyl, nitro, chloro, bromo, and fluoro; PA1 provided that at least one of R.sub.1 or R.sub.2 is hydrogen. The corresponding (Z)-styryl benzylsulfides are useful as intermediates in the preparation of the biologically active (Z)-styryl benzyl sulfones.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.