Method for grafting a substituted difluoromethyl group
US6203670A · kind A · utility
4Cited by
1References
28Claims
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Key dates
| Filing date | Apr 6, 1999 |
| Grant date | Mar 20, 2001 |
| Priority date | — |
| Expiry date | Apr 6, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C313/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided is a process for grafting a substituted difluoromethyl group onto a compound bearing at least one electrophilic substituent, comprising (i) contacting the compound bearing at least one electrophilic substituent with a nucleophilic reagent which comprises (a) a fluorocarboxylic acid having the formula Ea--CF.sub.2 --COOH, wherein Ea is an electron-withdrawing atom or group, the fluorocarboxylic acid being at least partially salified with an organic or inorganic cation and (b) a polar aprotic solvent, and (ii) exposing the resulting medium of reaction to the action of microwave energy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.