Measurement of lesion progression via mapping of chromatin texture features along progression curve
US6204064A · kind A · utility
Inventors
Key dates
| Filing date | Jan 30, 1999 |
| Grant date | Mar 20, 2001 |
| Priority date | — |
| Expiry date | Jan 30, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/25
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method is disclosed for quantitatively measuring the progression of a lesion toward malignant disease by digitizing images of clinical samples of biopsied lesions using a microphotometer that includes a video camera, and a computer that includes a video frame capture board. The digitized image is analyzed to locate the borders of cell nuclei within the captured video image, and one or more chromatin texture features within such nuclei are processed by the computer to arrive at a numerical value. This numerical value is compared to a monotonic progression curve that has been previously established by using the same procedure on known clinical samples ranging from normal tissue to malignant disease. The method can also be used to test the efficacy of chemopreventive drugs and treatments.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.