Ultrafine lightly coated superparamagnetic particles for MRI

US6207134A · kind A · utility

Assignee

• NYCOMED IMAGING AS · NO

Inventors

• Anne Kjersti Fahlvik · Oslo, NO
• Anne N.ae butted.vestad · Oslo, NO
• Helge G. Gundersen · Oslo, NO
• Per Strande · Oslo, NO
• Jo Klaveness · Oslo, NO
• Anne Jacobsen · Carpentersville, US

Key dates

• Filing date: Feb 3, 1999
• Grant date: Mar 27, 2001
• Expiry date: Feb 3, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/1872
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to particulate contrast agents, especially contrast agents for MR imaging having a metal oxide core which is preferably superparamagnetic iron oxide. The particulate contrast agents are provided with a low coating density of a polyelectrolyte coating agent selected from structural polysaccharides and synthetic polymers, especially polyaminoacids. Unlike conventional coated particulates, the new particles have reduced or no effect on cardiovascular parameters, platelet depletion, complement activation and blood coagulation.