Polypeptides with interleukin-16 activity, process for the preparation and use thereof

US6207144A · kind A · utility

Assignees

• Roche Diagnostics GMBH · DE
• Bundesrepublik Deutschland vertreten durch den Bundesminister fur Gesundheit · DE

Inventors

• Reinhard Kurth · Neu-Isenburg, DE
• Michael Baier · Frankfurt, DE
• Norbert Bannert · Frankfurt, DE
• Karin Metzner · Frankfurt, DE
• Albrecht Werner · Weinheim, DE
• Kurt Lang · Penzberg, DE

Key dates

• Filing date: Aug 27, 1998
• Grant date: Mar 27, 2001
• Expiry date: Aug 27, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A nucleic acid which can be used to express a polypeptide with interleukin-16 activity in a prokaryotic or eukaryotic host cell, wherein in the region coding for the said polypeptide the said nucleic acid a)corresponds to the DNA sequence of nucleotides 54-1175 from SEQ ID NO:1 or to its complementary strand, b) hybridizes with the DNA of nucleotide sequence 54-785 from SEQ ID NO:1 under stringent conditions, c) hybridizes with the DNA of nucleotide sequence 786-1175 from SEQ ID NO:1 under stringent conditions and at the 5' end begins with nucleotides 756-785 from SEQ ID NO:1 or a part thereof which codes for part of the sequence of amino acids 235-244 from SEQ ID NO:1 or d) it is a nucleic acid sequence which would hybridize under stringent conditions with the nucleic acid sequences defined by a) or b) without the degeneracy of the genetic code, codes for proteins with improved interleukin-16 activity.