Variants of thymidine kinase, nucleic acids encoding them, and methods of using them
US6207150A · kind A · utility
1Cited by
1References
37Claims
0Family size
Assignee
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Key dates
| Filing date | Aug 6, 1998 |
| Grant date | Mar 27, 2001 |
| Priority date | — |
| Expiry date | Aug 6, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a nucleic acid sequence characterized in that it is derived from the wild nucleic acid sequence coding for a thymidine kinase, said nucleic acid sequence having at least one mutation in the region corresponding to the ATP binding site and conveniently a second mutation in the N-terminal region and/or C-terminal region. It also relates to variants of the wild thymidine kinase and their use in genic therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.