aPL immunoreactive peptides, conjugates thereof and methods of treatment for aPL antibody-mediated pathologies
US6207160A · kind A · utility
26Cited by
16References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 6, 1996 |
| Grant date | Mar 27, 2001 |
| Priority date | — |
| Expiry date | Jun 6, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/645
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
aPL analogs that (a) bind specifically to B cells to which an aPL epitope binds and are disclosed. Optimized analogs lack T cell epitope(s) are useful as conjugates for treating aPL antibody-mediated diseases. Methods of preparing and identifying said analogs, methods of treatment using said analogs, methods and compositions for preparing conjugates of said analogs and diagnostic immunoassays for aPL antibodies are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.